A new antibiotic CJ-17,665 from Aspergillus ochraceus.

نویسندگان

  • Y Sugie
  • H Hirai
  • T Inagaki
  • M Ishiguro
  • Y J Kim
  • Y Kojima
  • T Sakakibara
  • S Sakemi
  • A Sugiura
  • Y Suzuki
  • L Brennan
  • J Duignan
  • L H Huang
  • J Sutcliffe
  • N Kojima
چکیده

A new antibiotic, CJ-17,665 (I) was isolated from the fermentation broth of Aspergillus ochraceus, CL41582. It inhibits growth of multi-drug resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 microg/ml, respectively. The structure contains a diketopiperazine and an indole N-oxide moiety that is unusual in natural products.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 54 11  شماره 

صفحات  -

تاریخ انتشار 2001